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The CIBBR-sponsored seminar series continues this听 Friday Sept.听27,听听featuring听Dr. Ricardo Rajsbaum from University of Texas Medical Branch.听听 He will be visiting campus as part of the MCBS Department Seminar sereies and will be providing a lecture from his research.

Topic:听Regulation of innate immunity and virus replication by the host ubiquitin system

When & Where:听Friday Sept. 27 2019, 12:10 - 1听p.m. in Rudman Hall G89

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Abstract:听The innate immune response involves activation of multiple signaling pathways that culminate in the production of type I interferons (IFN-I) and inflammatory cytokines, which together control virus infections. However, excessive cytokine production can result in exacerbated disease. To strike the right balance, these signaling pathways are regulated by different molecular processes, including the ubiquitin system. We will discuss novel molecular mechanism by which ubiquitin enzymes regulate host antiviral pathways, and how completely different pathogenic viruses (Nipah, Ebola, Zika and Influenza) repurpose the ubiquitin system to enhance virus replication.

Bio:听Ricardo Rajsbaum, Ph.D. is an associate professor in the Department of Microbiology and Immunology at the University of Texas Medical Branch, Galveston, Texas. Dr. Rajsbaum performed his Ph.D. in the laboratory of Anne O鈥橤arra at the MRC-NIMR, London, UK, and completed his postdoctoral training at Mount Sinai School of Medicine, New York, with Dr. Adolfo Garcia-Sastre. Dr. Rajsbaum's lab at UTMB studies the regulation of cytokine expression in immune cells, TLR and RIG-I-like receptor signaling, regulation and function of type-I IFNs, and virus鈥揾ost interactions, with a specific focus on the role of ubiquitin and TRIM E3-ubiquitin ligases in innate antiviral function.